Bronchodilators for Reactive Airway Disease
Jeffrey L. Segar, MD and Sarah B. Tierney, PharmD
Peer Review Status: Internally Peer Reviewed 12/19/12
(One MDI actuation delivers 100 mcg (0.1mg))
|Acute: 0.1 mg/kg via nebulization/MDI every 1-4 hours as needed. Can increase to 0.5 mg/kg.
Chronic: 0.1 mg/kg every 12 hours
|Increased heart rate, agitation|
(One MDI actuation delivers
90 mcg/18 mcg)
|1-2 puffs BID||Added anticholinergic effect. The combination of ipratropium with a beta-agonist produces more bronchodilation than either drug individually.|
|1-2 puffs BID||(R)-enantiomer of racemic albuterol and associated with less tachycardia|
|Methylxanthines||1Theophylline||LD: 5-6 mg/kg IV/PO followed by
MD: 2 mg/kg IV/PO every 8 hours
|Increased heart rate, irritability, arrhythmia, seizures.||Metabolism varies with age. Therapeutic levels (peak): 10-20 mg/L. Consider changing to a Q6h schedule if unable to achieve adequate levels after 4 weeks on therapy.|
- Monitoring serum levels is required. See “Use of Drug Monitoring Levels in the NICU” for more information.
- Lexi-Comp, Inc. Pediatric Drug Information. Accessed online. Updated annually.
- Thomas Reuters. Neofax. 24th Edition. 2011.