Tolerance of IVIG Administration to Neonates
Chetan A. Patel MD and Edward F. Bell, MD
Peer Review Status: Internally Peer Reviewed
IVIG should be administered by itself, with careful monitoring during the infusion. Vital signs should be monitored during the infusion (preferably q 15 min. X 2, then q hr). In the large multicenter trials involving infants, very few adverse reactions were noted during infusion. These consisted of mild increases or decreases in blood pressure, heart rate, or temperature (that were reversed by slowing the rate of infusion) or acute fluid overload. Since the dose of IVIG is equivalent to an approximately 10 ml/kg fluid bolus, the infusion is administered over several (typically 3 - 4) hours.
|Brand name||Form||Characteristics||Reconstituted In||Cautions|
|Gammagard® (Baxter)||0.5, 2.5, 5 and 10 g vials||pH 6.8, 2% glucose, 0.3% albumin||Sterile Water||Rate dependent side effects on HR, BP, Temperature|
|Gamimune N® (Miles-Cutter)||5% solutions (Premixed)||pH 4.25.||10% maltose (For Isotonicity)||Above; Hyperglycemia, and rare decreased pH|
|Sandoglobulin (Sandoz)||1, 3, and 6 g vials||pH 6.6, 5 or 10% sucrose (1.67 g)||0.9% NaCl, D5W, or sterile water||Above, Hyperglycemia|
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