Hepatorenal syndrome is a condition in which there is progressive kidney failure in a person with cirrhosis of the liver. It is a serious and often life-threatening complication of cirrhosis.
Causes, incidence, and risk factors
Hepatorenal syndrome occurs when there is a decrease in kidney function in a person with a severe liver disorder. Because less urine is removed from the body, nitrogen-containing waste products build up in the bloodstream (azotemia).
The disorder occurs in up to 1 in 10 patients who are in the hospital due to liver failure. It leads to kidney failure in people with:
Risk factors include:
- Blood pressure that falls when a person rises or suddenly changes position (orthostatic hypotension)
- Use of medicines called diuretics ("water pill")
- Gastrointestinal bleeding
- Recent abdominal fluid tap (paracentesis)
Signs and tests
This condition is diagnosed when other causes of kidney failure are ruled out by the appropriate tests.
A physical examination does not directly reveal kidney failure. However, the exam will usually show signs of chronic liver disease, including:
Other signs include:
- Abnormal reflexes
- Smaller testicle
- Dull sound in the belly area when tapped with the tips of the fingers
- Increased breast tissue (gynecomastia)
- Sores (lesions) on the skin
The following may be signs of kidney failure:
The following may be signs of liver failure:
The goal of treatment is to help your liver work better and to make sure your heart is pumping enough blood to your body.
Treatment is generally the same as kidney failure due to any cause.
- All unnecessary medicines should be stopped, especially ibuprofen and other NSAIDs, the antibiotic neomycin, and diuretics ("water pills").
- Dialysis may improve symptoms.
- Medications such as octreotide plus midodrine, albumin, or dopamine may be used to improve blood pressure and temporarily to help your kidneys work better.
- A nonsurgical shunt (known as TIPS) is used to relieve the symptoms of ascites and may help kidney function.
- Surgery to place a shunt (called a Levine shunt) from the abdominal space (peritoneum) to the jugular vein may also relieve some of the symptoms of kidney failure. Both procedures are risky and proper selection of patients is very important.
The predicted outcome is poor. Death is usually the result of a secondary infection or severe bleeding (hemorrhage).
Calling your health care provider
This disorder most often is diagnosed in the hospital during treatment for a liver disorder.
Garcia-Tsao G. Cirrhosis and its sequelae. In: Goldman L,Schafer AI, eds. Cecil Medicine. 24th ed. Philadelphia, PA: Saunders Elsevier; 2011:chap 156.
Schuppan D, Afdhal NH. Liver cirrhosis. Lancet. 2008;371:838-851.
Last reviewed 5/1/2012 by David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. George F. Longstreth, MD, Department of Gastroenterology, Kaiser Permanente Medical Care Program, San Diego, California. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M. Health Solutions, Ebix, Inc.
- The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition.
- A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions.
- Call 911 for all medical emergencies.
- Links to other sites are provided for information only -- they do not constitute endorsements of those other sites.
Any duplication or distribution of the information contained herein is strictly prohibited.